Friends of mine took their 92year old mother to get the vaccine. She had a slight cold but her doctor told her to go ahead and get vaccinated. The 3of them got the vaccine on Thursday. Sunday the mother was transported by Ambulance to the hospital. The slight cold was Covid and now she is declining with pneumonia. Saturday the freshly vaccinated 64 year old son got Covid from his mother and had a plasma fusion days later. question: * Did the antibodies created by the vaccine added to the antibodies naturally created by Covid cause a a hyper response in the immune system .. and lead to a cytokine storm ?
* is it too late to use HCQ/azithro for the mother ?
Sorry, I didn't see the question about HCQ/azithro.
No, it isn't too late for HCQ/azithro therapy for the mother.
Regarding your friend's 92 yo mother, the vaccination most probably had nothing to do with the deterioration and clinical progression. Rather, the mother simply had progressive Covid. First, the vaccine was given after she had the infection. Second, the mother was hospitalized 3-4 days after the vaccine, too early for a vaccine triggered immune response to develop.
Regarding vaccines, we are seeing some worse reactions in pts with a history of Covid. This group just being looked at more closely. The CDC feels that pts with a history of Covid should get the vaccine. I and other doctors have heard anecdotal stories of pts who had Covid months earlier developing more protracted reactions from the vaccine. The reactions include fatigue and joint aches and last 2-3 days.
Sinai and other groups have reported that those pts with antibodies against SARS-CoV-2 as the result of natural infections -
1. Have side effects more frequently than those who don't;
2. Develop very high antibody levels after a single dose.
It may be that those who anti-SARS-CoV-2 antibodies already only need a single dose. This makes sense, of course. Those of us who are immune naive to SARS-CoV-2 develop a moderate immune response after the first dose but then a much stronger immune response after the second dose of the Pfizer or Moderna vaccines. Accordingly, side effects or reactions to naive hosts to the first shot are mild but worse with the second dose of the vaccine. This is expected and is a good thing.
Pts with anti-SARS-CoV-2 antibodies essentially have already had the "first dose" from their Covid infection, meaning their immune systems are primed to respond to the first dose. So, it is expected that their first dose side effects or reactions would be stronger.
PLEASE DO NOT LET A HISTORY OF COVID STOP YOU FROM GETTING THE VACCINE.
If you think you had Covid and don’t want to get the vaccine, please, please at least check your antibodies against the virus, SARS-CoV-2, before making this decision.
· If you don’t have any antibodies, you have no protection against the virus.
· If you do have antibodies, I would still recommend getting at least one dose of the vaccine.
We don’t know how good your own antibodies are at protecting you against the virus. We know the antibodies induced by the vaccine are very good at protecting you against Covid.
SMS